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Could Viruses Promote Health?

by 5m Editor
17 August 2009, at 9:58am

US - Agricultural Research Service (ARS) scientists think that virus enzymes may promote human and animal health.

Could viruses be good for you? Scientists with the Agricultural Research Service (ARS) have shown that enzymes from bacteria-infecting viruses known as phages could have beneficial applications for human and animal health.

Phage enzymes called endolysins attack bacteria by breaking down their cell walls. Unlike antibiotics, which tend to have a broad range, endolysins are comparatively specific, targeting unique bonds in the cell walls of their hosts. This is significant because it means non-target bacteria could be less likely to develop resistance to endolysins.


ARS studies have shown that enzymes from bacteriophages (like the one shown) can be used to fight multi-drug-resistant bacterial pathogens, such as MRSA

Researchers at the ARS Animal Biosciences and Biotechnology Laboratory in Beltsville, Maryland, in collaboration with federal, university and industry scientists, have developed and are patenting technology to create powerful antimicrobials by fusing genetic material from multiple cell-wall-degrading endolysins. Now the researchers are collaborating with biopharmaceutical companies to evaluate and further develop the technology.

Studies led by ARS biologist, David M. Donovan, show that phage enzymes could be used to wipe out multi-drug-resistant pathogens that affect both animals and humans, such as methicillin resistant Staphylococcus aureus, also known as MRSA.

The scientists showed that the enzymes can knock out pathogens in biofilms, which are matrices of microorganisms that can attach to a variety of surfaces. Biofilms are resistant to antibiotics and contribute to many human infections.

In a related study, the scientists showed that using the endolysins lysostaphin and LysK in concert inhibited the growth of staphylococcal strains that cause mastitis in cattle and staph infections in humans.

This research was published recently in the journal, Biotech International.