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Mycofix More Effective against Toxins

by 5m Editor
23 September 2010, at 9:25am

AUSTRIA - Putting Mycofix® to the test in several in vitro and in vivo experiments involving ergot and endotoxin poisoning, Biomin proves once again its leading reputation in (myco)toxins control and management.

Animal health studies have documented the harm caused by ergot and endotoxin poisoning in animals. These two categories of toxins are blamed for a range of ailments. Ergot alkaloids may lead to poor feathering and lesions forming on chickens, fescue foot in ruminants and shrunken udders in sows while endotoxins are responsible for endotoxic shock and death. Overall, both groups of substances were found to negatively impact reproduction, feed intake and consequently weight gain among all animals, with consequences of financial losses for the producer.

Ergot alkaloids are commonly associated with an increase in the occurrence of Claviceps spp. fungi in cereal grains and Neotyphodium spp. fungi especially in tall fescue and perennial ryegrass particularly during wet seasons of spring and early summer. Among the predominant forms of alkaloids, tests by Biomin on batch samples of raw and finished feed ingredients found ergotamine and ergocristine to be among the most commonly occurring.

Endotoxins, on the other hand, are released by bacteria, particularly during cytokinesis and destabilisation of cell membrane, and react with blood proteins and cytokines to trigger changes in the immune response. Unlike ergot alkaloids which are toxins produced by plants, endotoxins are derived from air-borne bacteria or bacteria found in food, water and waste substances, as well as through endogenous sources such as the gastrointestinal tract and colonized mucosa.

To test the effects of Biomin's Mycofix product line on ergot alkaloids, Mycofix Plus was administered in ex vivo trials with swine gastric juice and rumen fluid. Adsorption rates for ergine, ergotamine and ergovaline were recorded at 56 per cent, 86 per cent and 90 per cent, respectively, in gastric juice and 68 per cent, 85 per cent and 86 per cent in rumen fluid. Recent in vitro trials of Mycofix in dry lick stones indicated adsorption rates of 91 per cent and 98 per cent for ergotamine and 84 per cent and 96 per cent for ergovaline at pH values of 3.5 and 6.5, respectively.

For endotoxins, Mycofix was found to promote the adsorption of endotoxins but, most importantly, to positively counter the overall inflammatory effects of these substances. The latter is achieved by a correct selection of yeast, plant and algae extracts which work in an harmonious way to increase the production of anti-inflammatory cytokine (IL-10) and to promote the activity of macrophages whilst decreasing the production of the pro-inflammatory ones (IL-6 and TNFa).

With these two new benefits against ergot alkaloids and endotoxins, the Mycofix product line has, once again, been proven to be the best approach to counteract a great range of (myco)toxins. Aflatoxins, fumonisins, ergot alkaloids and endotoxins are adsorbed by selected clay minerals; zearalenone, ochratoxins and the large family of trichothecenes are biotransformed into less or non-toxic metabolites. Bioprotection ensures the hepato- and immune-protection through plant and algae extracts, the latter especially important in the case of an endotoxin challenge.