Book Contents

Histopathology and Cytology of
Poultry Diseases
By Ivan Dinev, DVM, PhD


MYELOCYTOMATOSIS

Fig. 1. Myelocytomatosis (MC) is characterized
by proliferation of immature
cells from the granulocyte order
– myelocytes and promyelocytes. It
has an aleukaemic character. Occurs
independently or in association with
a number of other neoplastic diseases.
Atypical morphological forms
are possible. Histologically, myelocytomas
are easily distinguinshed. Most
commonly, they have a perivascular
localization. Growth of myelocytes
with a relatively high degree of maturity
and well formed eosinophilic
granules in a liver cross-section. H/E,
Bar = 50 µm.

Fig. 1. Myelocytomatosis (MC) is characterized by proliferation of immature cells from the granulocyte order – myelocytes and promyelocytes. It has an aleukaemic character. Occurs independently or in association with a number of other neoplastic diseases. Atypical morphological forms are possible. Histologically, myelocytomas are easily distinguinshed. Most commonly, they have a perivascular localization. Growth of myelocytes with a relatively high degree of maturity and well formed eosinophilic granules in a liver cross-section. H/E, Bar = 50 µm.

 
Fig. 2. Atrophic degenerative alterations
resulting from compression in a
case of intensive myelocyte proliferation
in the liver. H/E, Bar = 40 µm.

Fig. 2. Atrophic degenerative alterations resulting from compression in a case of intensive myelocyte proliferation in the liver. H/E, Bar = 40 µm.

 
Fig. 3. Focal intertubular myelocyte
proliferations in the kidney. H/E, Bar
= 25 µm.

Fig. 3. Focal intertubular myelocyte proliferations in the kidney. H/E, Bar = 25 µm.

 
Fig. 4. Numerous myelocytes in the
peripheral blood of a guineafowl
keet, 95 days after challenge with
an ALV-J isolate. H/E, Bar = 10 µm.

Fig. 4. Numerous myelocytes in the peripheral blood of a guineafowl keet, 95 days after challenge with an ALV-J isolate. H/E, Bar = 10 µm.

 
Fig. 5. Blood smear from a hen with
myelocytomatosis. A picture of anaemia
– anisocytosis, poikilocytosis,
two-nucleus erythrocyte (arrow).
H/E, Bar = 10 µm.

Fig. 5. Blood smear from a hen with myelocytomatosis. A picture of anaemia – anisocytosis, poikilocytosis, two-nucleus erythrocyte (arrow). H/E, Bar = 10 µm.

 
Fig. 6. Blood smear from a hen with
myelocytomatosis. A picture of anaemia
– anisocytosis, poikilocytosis,
erythrocyte without nucleus (arrow).
H/E, Bar = 10 µm.

Fig. 6. Blood smear from a hen with myelocytomatosis. A picture of anaemia – anisocytosis, poikilocytosis, erythrocyte without nucleus (arrow). H/E, Bar = 10 µm.

 

MYELOCYTOMATOSIS - ASSOCIATED NEOPLASMS

Fig. 7. Rhabdomyosarcoma, pectoral
muscle, hen. An extremely high
polymorphism of cells constituting
tumour parenchyma. H/E, Bar = 25
µm.

Fig. 7. Rhabdomyosarcoma, pectoral muscle, hen. An extremely high polymorphism of cells constituting tumour parenchyma. H/E, Bar = 25 µm.

 
Fig. 8. Rhabdomyosarcoma located
in the thigh muscle of a hen. An area
with multiple hyperchromatic, polynuclear
cells. H/E, Bar = 25 µm.

Fig. 8. Rhabdomyosarcoma located in the thigh muscle of a hen. An area with multiple hyperchromatic, polynuclear cells. H/E, Bar = 25 µm.

 
Fig. 9. Leiomyosarcoma, mesosalpinx.
Polygonal giant cells with hyperchromatic
nuclei. H/E, Bar = 25 µm.

Fig. 9. Leiomyosarcoma, mesosalpinx. Polygonal giant cells with hyperchromatic nuclei. H/E, Bar = 25 µm.

 
Fig. 10. Leiomyosarcoma, small intestine.
Prolongations of polynuclear
symplastic elements (arrows). H/E,
Bar = 30 µm

Fig. 10. Leiomyosarcoma, small intestine. Prolongations of polynuclear symplastic elements (arrows). H/E, Bar = 30 µm

 
Fig. 11. Leiomyosarcoma, small intestine.
Extraordinary (“monstrous”)
multinuclear giant cell with intracytoplasmic
vacuoles. H/E, Bar = 25 µm.

Fig. 11. Leiomyosarcoma, small intestine. Extraordinary (“monstrous”) multinuclear giant cell with intracytoplasmic vacuoles. H/E, Bar = 25 µm.

 
Fig. 12. Degenerative necrobiotic
process of a leiomyosarcoma metastasis
in the liver of a hen. H/E, Bar =
25 µm.

Fig. 12. Degenerative necrobiotic process of a leiomyosarcoma metastasis in the liver of a hen. H/E, Bar = 25 µm.

 
Fig. 13. Myxosarcoma, liver, hen. H/E,
Bar = 25 µm.

Fig. 13. Myxosarcoma, liver, hen. H/E, Bar = 25 µm.

 
Fig. 14. Fibro-myxosarcoma, metastatic
focus in the cervical subcutis
from a primary mixed mesenchymal
tumour in the alimentary tract. H/E,
Bar = 40 µm.

Fig. 14. Fibro-myxosarcoma, metastatic focus in the cervical subcutis from a primary mixed mesenchymal tumour in the alimentary tract. H/E, Bar = 40 µm.

 
Fig. 15. Carcinosarcoma, pancreas.
Tubulous glandular epithelial formations
- carcinomatous component
(arrow), among the liposarcomatous
part of the parenchyma. H/E, Bar =
30 µm.

Fig. 15. Carcinosarcoma, pancreas. Tubulous glandular epithelial formations - carcinomatous component (arrow), among the liposarcomatous part of the parenchyma. H/E, Bar = 30 µm.

 
Fig. 16. Carcinosarcoma in the region
of the infraorbital sinus. Adeno- (a)
and cystadenocarcinomatous (ca)
structures among the sarcomatous
part of the parenchyma. H/E, Bar =
30 µm.

Fig. 16. Carcinosarcoma in the region of the infraorbital sinus. Adeno- (a) and cystadenocarcinomatous (ca) structures among the sarcomatous part of the parenchyma. H/E, Bar = 30 µm.

 
Fig. 17. Nephroblastoma. An area of
embryonal-like cells of mesenchymal
and epithelial origin. Simultaneous
presence of tubules (arrow) at a different
stage of development. Young
nondifferentiated tubules are not
clearly distinguished among the sarcomatous
structures. H/E, Bar = 30
µm.

Fig. 17. Nephroblastoma. An area of embryonal-like cells of mesenchymal and epithelial origin. Simultaneous presence of tubules (arrow) at a different stage of development. Young nondifferentiated tubules are not clearly distinguished among the sarcomatous structures. H/E, Bar = 30 µm.

 
Fig.18. Nephroblastoma. A group
of poorly differentiated glomerular
structures among the neoplastic tissue
of a fibrous type. H/E, Bar = 50 µm.

Fig.18. Nephroblastoma. A group of poorly differentiated glomerular structures among the neoplastic tissue of a fibrous type. H/E, Bar = 50 µm.

 
Fig. 19. Nephroblastoma. Young tubules
with a rosette-like structure.
H/E, Bar = 50 µm.

Fig. 19. Nephroblastoma. Young tubules with a rosette-like structure. H/E, Bar = 50 µm.

 
Fig. 20. Kidney, cystadenocarcinoma.
H/E, Bar = 35 µm.

Fig. 20. Kidney, cystadenocarcinoma. H/E, Bar = 35 µm.

 
Fig. 21. Ovary, granulosa-theca cell
tumour. Islets of anaplastic cells, delineated
by well-developed stroma
of fibrous and smooth muscle fibres.
H/E, Bar = 30 µm.

Fig. 21. Ovary, granulosa-theca cell tumour. Islets of anaplastic cells, delineated by well-developed stroma of fibrous and smooth muscle fibres. H/E, Bar = 30 µm.

 
Fig. 22. Ovary, granulosa-theca cell
tumour. Tubulus-like formations (arrow)
of the tumour parenchyma.
H/E, Bar = 25 µm.

Fig. 22. Ovary, granulosa-theca cell tumour. Tubulus-like formations (arrow) of the tumour parenchyma. H/E, Bar = 25 µm.

 
Fig. 23. Haemangiosarcoma of the
small intestinal wall. The parenchyma
consists of anastomizing canals with
papilliferous depressions. H/E, Bar =
50 µm.

Fig. 23. Haemangiosarcoma of the small intestinal wall. The parenchyma consists of anastomizing canals with papilliferous depressions. H/E, Bar = 50 µm.

 
Fig. 24. Liver cell carcinoma. Growth
of rosette-like and tubulous structures
(a) surrounded by a dense fibrous
and well-vascularized capsule.
H/E, Bar = 50 µm.

Fig. 24. Liver cell carcinoma. Growth of rosette-like and tubulous structures (a) surrounded by a dense fibrous and well-vascularized capsule. H/E, Bar = 50 µm.

 
Fig. 25. Cholangioma, liver, hen. Well
differentiated structures resembling
biliary ducts. H/E, Bar = 35 µm.

Fig. 25. Cholangioma, liver, hen. Well differentiated structures resembling biliary ducts. H/E, Bar = 35 µm.

 
Fig. 26. Intrahepatic cholangiocarcinoma.
Irregular glandular papilliferous
neoplastic formations. Marked
stromal desmoplasia. Fibrous tissue
surrounding the neoplastic glands.
H/E, Bar = 50 µm.

Fig. 26. Intrahepatic cholangiocarcinoma. Irregular glandular papilliferous neoplastic formations. Marked stromal desmoplasia. Fibrous tissue surrounding the neoplastic glands. H/E, Bar = 50 µm.

 
Fig. 27. Extrahepatic cholangiocarcinoma.
Glandular epithelial carcinoma
to the extrahepatic biliary tract. H/E,
Bar = 25 µm.

Fig. 27. Extrahepatic cholangiocarcinoma. Glandular epithelial carcinoma to the extrahepatic biliary tract. H/E, Bar = 25 µm.

 
Fig. 28. Glioblastoma, symmetrical
neoplastic foci, brain, hen. H/E, Bar
= 35 µm.

Fig. 28. Glioblastoma, symmetrical neoplastic foci, brain, hen. H/E, Bar = 35 µm.

 
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